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This SOP shall be applicable for cleaning equipment and accessories in the Production Department. 3.0 RESPONSIBILITY: 3.1 ExExecution:rator 3.2 Checking : Pharmacist and Above 4.0 ACCOUNTABILITY: HOD-Production 5.0 PROCEDURE: 5.1 CLEANING OF MAJOR EQUIPMENTS 5.1.1 Dismantle the movable parts of the major equipment.

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Cryomilling enables the production of both micron and nano-sized particles but it has not been widely adopted in the pharmaceutical industry for the milling of drugs. Sugimoto et al. studied the cryogenic co-milling of phenytoin and polyvinylpyrrolidone as a means to improve the dissolution rate of the drug.

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